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THE TOTAL SYNTHESIS OF STRYCHNINE

✍ Scribed by Woodward, R. B.; Cava, Michael P.; Ollis, W. D.; Hunger, A.; Daeniker, H. U.; Schenker, K.


Book ID
120930967
Publisher
American Chemical Society
Year
1954
Tongue
English
Weight
351 KB
Volume
76
Category
Article
ISSN
0002-7863

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Total Synthesis of (-)-Strychnine via the Wieland-Gumlich Aldehyde. -A novel synthesis of optically pure (-)-strychnine (XI) is presented involving the easy generation of enantiopure octahydroindolone (III), the palladium-catalyzed piperidine ring closure with stereoselective incorporation of the E-