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Total Synthesis of (−)-Strychnine via the Wieland–Gumlich Aldehyde

✍ Scribed by Daniel Solé; Josep Bonjoch; Silvina García-Rubio; Emma Peidró; Joan Bosch


Publisher
John Wiley and Sons
Year
1999
Tongue
English
Weight
89 KB
Volume
38
Category
Article
ISSN
0044-8249

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ChemInform Abstract: Total Synthesis of
✍ Daniel Sole; Josep Bonjoch; Silvina Garcia-Rubio; Emma Peidro; Joan Bosch 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 35 KB 👁 1 views

Total Synthesis of (-)-Strychnine via the Wieland-Gumlich Aldehyde. -A novel synthesis of optically pure (-)-strychnine (XI) is presented involving the easy generation of enantiopure octahydroindolone (III), the palladium-catalyzed piperidine ring closure with stereoselective incorporation of the E-