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The Total Synthesis of (+)-Retronecine

โœ Scribed by GEISSMAN, T. A.; WAISS, ANTHONY C.


Book ID
119966865
Publisher
American Chemical Society
Year
1962
Tongue
English
Weight
471 KB
Volume
27
Category
Article
ISSN
0022-3263

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## Abstract Retronecine (7ฮฒโ€hydroxyโ€1โ€hydoxymethylโ€1,2โ€dehydroโ€8ฮฑโ€pyrrolizidine) (II) which is prepared from the hydrolysis of monocrotaline (I) was oxidized with manganese dioxide in the presence of potassium cyanide to methyl 1,2โ€dehydroโ€7ฮฒโ€hydroxyโ€8ฮฑโ€pyrrolizidineโ€1โ€carboxlate (III). Retronecine