Total synthesis of optically active integerrimine, a twelve-membered dilactonic pyrrolizidine alkaloid of retronecine type. III. Regioselective elaboration of the unsymmetrical twelve-membered dilactone and total synthesis of (-)-integerrimine

✍ Scribed by Haruki Niwa; Yasuyoshi Miyachi; Youichi Uosaki; Akio Kuroda; Hiroyuki Ishiwata; Kiyoyuki Yamada

• Publisher: Elsevier Science
• Year: 1986
• Tongue: French
• Weight: 142 KB
• Volume: 27
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(00)85017-0

✦ Synopsis

The first enantioselective synthesis of optically active integerrimine, the twelve-membered dilactonic pyrrolizidine alkaloid has been achieved.