## Recently, we reported' the total synthesis of (*)-isoretronecanol (1) and (+)-8-coniceine (2). A key step in each of these syntheses utilized the acid-catalyzed rearrangement of a cyclopropylimine to generate the 3-phenylthio-2-pyrroline synthon (2). The latter intermediate serves as a relative
โฆ LIBER โฆ
The Total Synthesis of Ipalbidine and Ipalbine
โ Scribed by A. E. Wick; P. A. Bartlett; D. Dolphin
- Publisher
- John Wiley and Sons
- Year
- 1971
- Tongue
- German
- Weight
- 686 KB
- Volume
- 54
- Category
- Article
- ISSN
- 0018-019X
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โฆ Synopsis
Zusammenfussung. Eine Totalsynthese des Hexahydroindolizin-Alkaloids Ipalbidin (7) und seines P-D-Glucosids Ipalbin (1) wird beschricben. Dcr zentrale Syntheseschritt besteht aus ciner N-Acylierung des vinylogen Amidsystems 3, gefolgt von einer internen Kondensation zum penta-' I Upon completion of this manuscript, a synthesis of racemic ipalbidinc was reported [Z].
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