The pentacyclic skeleton 10 of the aspidospermine group of indole alkaloids has been constructed from hexahydrocarbazol-4-one 2 with high stereoselectivity. The synthesis of(k) 19-0~0 aspidofractinine 12, a direct precursor of aspidofractinine 4, illustrates the usefulness of this new general strat
The total synthesis of (±)-aspidofractinine
✍ Scribed by Yoshio Ban; Yusushi Honma; Takeshi Oishi
- Book ID
- 104226068
- Publisher
- Elsevier Science
- Year
- 1976
- Tongue
- French
- Weight
- 218 KB
- Volume
- 17
- Category
- Article
- ISSN
- 0040-4039
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📜 SIMILAR VOLUMES
The oxindolic methylketone Z. was cyclized in one step fo the hexacyclic ketolactam 9 with acid. (?)-Aspidofractinine a was prepared by sequential reduction of 3. The model oxindolic methylketone 11, when reacted with acid, gave compounds J-2 and w. The intra-molecular cyclization of a methylketone
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