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The Thymus and the Pathogenesis of Myasthenia Gravis

✍ Scribed by A.I. Levinson; L.M. Wheatley


Book ID
112240742
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
142 KB
Volume
78
Category
Article
ISSN
1090-2341

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Myasthenia gravis (MG) and its animal model experimental autoimmune myasthenia gravis (EAMG) are caused by autoantibodies against nicotinic acetylcholine receptor (AChR) in skeletal muscle. The production of anti-AChR antibodies is mediated by cytokines produced by CD4+ and CD8+ T helper (Th) cells.

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In 5-10% of all patients with typical generalised myasthenia gravis (MG), serum antibody to the acetylcholine receptor (AChR) is undetectable. To determine whether these represent a distinct subgroup, we have compared the thymuses of 14 seronegatives, 70 seropositives and 12 non-myasthenic controls.