The Thymus and the Pathogenesis of Myasthenia Gravis
β Scribed by A.I. Levinson; L.M. Wheatley
- Book ID
- 112240742
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- English
- Weight
- 142 KB
- Volume
- 78
- Category
- Article
- ISSN
- 1090-2341
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π SIMILAR VOLUMES
Myasthenia gravis (MG) and its animal model experimental autoimmune myasthenia gravis (EAMG) are caused by autoantibodies against nicotinic acetylcholine receptor (AChR) in skeletal muscle. The production of anti-AChR antibodies is mediated by cytokines produced by CD4+ and CD8+ T helper (Th) cells.
In 5-10% of all patients with typical generalised myasthenia gravis (MG), serum antibody to the acetylcholine receptor (AChR) is undetectable. To determine whether these represent a distinct subgroup, we have compared the thymuses of 14 seronegatives, 70 seropositives and 12 non-myasthenic controls.