𝔖 Bobbio Scriptorium
✦   LIBER   ✦

The thioredoxin system—From science to clinic

✍ Scribed by Stephan Gromer; Sabine Urig; Katja Becker

Book ID
102946238
Publisher
John Wiley and Sons
Year
2003
Tongue
English
Weight
975 KB
Volume
24
Category
Article
ISSN
0198-6325

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

The thioredoxin system—formed by thioredoxin reductase and its characteristic substrate thioredoxin—is an important constituent of the intracellular redox milieu. Interactions with many different metabolic pathways such as DNA‐synthesis, selenium metabolism, and the antioxidative network as well as significant species differences render this system an attractive target for chemotherapeutic approaches in many fields of medicine—ranging from infectious diseases to cancer therapy. In this review we will present and evaluate the preclinical and clinical results available today. Current trends in drug development are emphasized. © 2003 Wiley Periodicals, Inc. Med Res Rev, 24, No. 1, 40–89, 2004

📜 SIMILAR VOLUMES

The Thioredoxin System — From Science to
The Thioredoxin System — From Science to Clinic
✍ Stephan Gromer; Sabine Urig; Katja Becker 📂 Article 📅 2004 🏛 John Wiley and Sons ⚖ 50 KB

## Abstract For Abstract see ChemInform Abstract in Full Text.

The thioredoxin system from Streptomyces
The thioredoxin system from Streptomyces coelicolor
✍ Petra Štefanková; Dušan Perečko; Imrich Barák; Marta Kollárová 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 119 KB

## Abstract This paper describes the cloning, purification and characterization of thioredoxin (TrxA) and thioredoxin reductase (TrxR) from bacterial strain __Streptomyces coelicolor__ . The genes of __S. coelicolor__ encoding TrxA and TrxR were amplified by polymerase chain reaction, inserted into

From clones to clinic
From clones to clinic
✍ John Morser 📂 Article 📅 1982 🏛 Elsevier Science 🌐 English ⚖ 160 KB