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The TGF-β response to Leishmania chagasi in the absence of IL-12

✍ Scribed by Mary E. Wilson; Thomas J. Recker; Nilda E. Rodriguez; Betty M. Young; Kindra K. Burnell; Judy A. Streit; Joel N. Kline


Publisher
John Wiley and Sons
Year
2002
Tongue
English
Weight
186 KB
Volume
32
Category
Article
ISSN
0014-2980

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Transforming growth factor-beta (TGF-beta) signaling is initiated following heterodimerization of the type II TGF-beta receptor (TbetaRII) with the type I TGF-beta receptor (TbetaRI). Both receptors are required for TGF-beta responsiveness. In the present study, we characterized the actions of TGF-b