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The Tertiary Amine Nitrogen Atom of Piperazine Sulfonamides as a Novel Determinant of Potent and Selective β3-Adrenoceptor Agonists

✍ Scribed by Maria Grazia Perrone; Laura Bleve; Ernesto Santandrea; Paola Vitale; Mauro Niso; Antonio Scilimati

Book ID: 102806153
Publisher: John Wiley and Sons
Year: 2009
Tongue: English
Weight: 582 KB
Volume: 4
Category: Article
ISSN: 1860-7179
DOI: 10.1002/cmdc.200900292

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✦ Synopsis

Scheme 1. Reagents and conditions: a) NaH, DMF (anhyd), RT; b) CH 3 OH (anhyd), reflux; c) di-tert-butyldicarbonate, CH 2 Cl 2 , RT; d) H 2 (10 atm), 20 % Pd(OH) 2 /C, EtOAc, RT; e) HSO 3 Cl, 0 8C; f) CH 2 Cl 2 , RT.

Scheme 2. Reagents and conditions: a) TFA in CH 2 Cl 2 , 08C; b) 1 n NaOH, THF, RT.

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