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Discovery of Novel N -Phenylglycine Derivatives as Potent and Selective β 3 -Adrenoceptor Agonists for the Treatment of Frequent Urination and Urinary Incontinence

✍ Scribed by Tanaka, Nobuyuki; Tamai, Tetsuro; Mukaiyama, Harunobu; Hirabayashi, Akihito; Muranaka, Hideyuki; Akahane, Satoshi; Miyata, Hiroshi; Akahane, Masuo

Book ID
127335560
Publisher
American Chemical Society
Year
2001
Tongue
English
Weight
128 KB
Volume
44
Category
Article
ISSN
0022-2623

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Scheme 1. Reagents and conditions: a) NaH, DMF (anhyd), RT; b) CH 3 OH (anhyd), reflux; c) di-tert-butyldicarbonate, CH 2 Cl 2 , RT; d) H 2 (10 atm), 20 % Pd(OH) 2 /C, EtOAc, RT; e) HSO 3 Cl, 0 8C; f) CH 2 Cl 2 , RT. Scheme 2. Reagents and conditions: a) TFA in CH 2 Cl 2 , 08C; b) 1 n NaOH, THF, RT