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The terfenadine/β-cyclodextrin inclusion complex

✍ Scribed by Enrico Redenti; Massimo Pasini; Paolo Ventura; Alberto Spisni; Maria Vikmon; József Szejtli

Publisher
Springer Netherlands
Year
1994
Tongue
English
Weight
533 KB
Volume
15
Category
Article
ISSN
0923-0750

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The interaction of a nonsteroidal anti-inflammatory drug, naproxen, with \(\beta\)-CD has been studied by several analytical techniques, including 1-D and 2-D proton NMR, fluorescence spectroscopy, and FAB-MS. The negative ion FAB-MS confirmed the existence of a 1:1 inclusion complex of naproxen and

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✍ I. Bratu; J. M. Gavira-Vallejo; A. Hernanz; M. Bogdan; Gh. Bora 📂 Article 📅 2004 🏛 Wiley (John Wiley & Sons) 🌐 English ⚖ 108 KB 👁 1 views

## Abstract An inclusion complex of fenbufen with β‐cyclodextrin (β‐CD) in aqueous solution was characterized by ^1^H‐NMR spectroscopy. The [1:1] stoichiometry was determined and a stability constant of several 1000s (__M__^−1^) was calculated. The geometry of the inclusion complex was established