The temporary effect of proximal gastric vagotomy on experimental duodenal ulcers and gastric secretion

✍ Scribed by S. N. Joffe; R. D. Bapat

• Publisher: John Wiley and Sons
• Year: 1979
• Tongue: English
• Weight: 385 KB
• Volume: 66
• Category: Article
• ISSN: 0007-1323
• DOI: 10.1002/bjs.1800660405

✦ Synopsis

Summary

A proximal gastric vagotomy (PGV) prevented experimental duodenal ulcers in rats for only 5 days and thereafter all rats developed duodenal ulceration. In sham-operated rats the mean stimulated gastric acid output was 186 μmol/60 min. Immediately following a PGV there was a significant decrease in gastric juice volume and aridity (P < 0.001) with a fall in the mean stimulated acid output to 12 μmo1/60 min. On the seventh day after vagotomy the stimulated acid output (volume and concentration) significantly increased to 88 μmo1/60 min (P < 0.001). When the dose of gastric secretagogues was reduced by 50 per cent, a PGV on day 0 prevented any changes occurring in the duodenal mucosa, but when repeated at 4 weeks after a PGV the severity of duodenal ulcers in vagotomized rats was greater than in those having had a sham operation (P < 0.05). This transient effect of a PGV on duodenal ulcerogenesis and gastric secretion may be due to recovery of the parietal cell mass.