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The TCR-mediated signaling pathways that control the direction of helper T cell differentiation

✍ Scribed by Toshinori Nakayama; Masakatsu Yamashita


Book ID
116885641
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
379 KB
Volume
22
Category
Article
ISSN
1044-5323

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Dendritic cells (DC) initiate T cell responses and direct the class of T cell immunity through the production of Th-polarizing cytokines. In the mouse, immunization with CD8alpha(+) DC has led to Th1 priming whereas immunization with CD8alpha(-) DC has been associated with Th2 induction. Here, we us