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The TAK1–TRAF6 signalling pathway

✍ Scribed by Marene Landström

Book ID
116307877
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
566 KB
Volume
42
Category
Article
ISSN
1357-2725

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TAB2, a Novel Adaptor Protein, Mediates
TAB2, a Novel Adaptor Protein, Mediates Activation of TAK1 MAPKKK by Linking TAK1 to TRAF6 in the IL-1 Signal Transduction Pathway
✍ Giichi Takaesu; Satoshi Kishida; Atsushi Hiyama; Kyoko Yamaguchi; Hiroshi Shibuy 📂 Article 📅 2000 🏛 Elsevier Science 🌐 English ⚖ 382 KB

The TAK1 MAPKKK mediates activation of JNK and NF-KB in the IL-1-activated signaling pathway. Here we report the identification of TAB2, a novel intermediate in the IL-1 pathway that functionally links TAK1 to TRAF6. Expression of TAB2 induces JNK and NF-kappaB activation, whereas a dominant-negativ