Activation of gef-h1, a guanine nucleoti
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Marcus Brecht; Agatha C.M. Steenvoorden; John G. Collard; Susanne Luf; Dorothee
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Article
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2004
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John Wiley and Sons
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French
⚖ 294 KB
Several oncogenes isolated by the NIH/3T3 transformation assay, i.e., dbl, dbs, lbc, lfc, lsc, net, ost and tim, contain a Dbl homology (DH) and a pleckstrin-homology (PH) domain and act as GEFs (guanine nucleotide exchange factors) for Rho-like GTPases. In a search for genes with oncogenic potentia