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The t(2;13) translocation in rhabdomyosarcoma

✍ Scribed by B. Gibbons; B.D. Young; D. Rowe; J.S. Malpas


Book ID
119105255
Publisher
Elsevier Science
Year
1991
Tongue
English
Weight
39 KB
Volume
52
Category
Article
ISSN
0165-4608

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Rhabdomyosarcoma, a small-. round-cell tumor of skeletal muscle, is the most common soft tissue sarcoma found in children. A specific and unique chromosomal translocation, t(2;13)(q35;q14), has been described cytogenetically in a subset of these tumors and is most often associated with the alveolar

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The chromosomal translocation t(2;13)(q35;q14) has been reported in alveolar paediatric rhabdomyosarcoma. The rearrangement leads to the juxtaposition of the PAX-3 and FORKHEAD genes and the production of a fusion protein with putative transcriptional regulatory activity. The diagnostic potential of

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