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The synthetic peptide octraphin TPLVTLFK is a selective agonist of nonopioid β-endorphin receptor

✍ Scribed by Yu. N. Nekrasova; E. V. Navolotskaya

Book ID
111471973
Publisher
SP MAIK Nauka/Interperiodica
Year
2012
Tongue
English
Weight
219 KB
Volume
6
Category
Article
ISSN
1990-7478

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Binding of synthetic peptide TPLVTLFK to
Binding of synthetic peptide TPLVTLFK to nonopioid beta-endorphin receptor on rat brain membranes
✍ Yuliia N. Nekrasova; Vladimir B. Sadovnikov; Yury A. Zolotarev; Elena V. Navolot 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 129 KB

## Abstract The synthetic peptide TPLVTLFK corresponding to the sequence 12–19 of β‐endorphin (referred to as octarphin) was found to bind to high‐affinity naloxone‐insensitive binding sites on membranes isolated from the rat brain cortex (__K__~d~ = 2.6 ± 0.2 nM). The binding specificity study rev