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The Synthesis of Two Potent β-3 Adrenergic Receptor Agonists

✍ Scribed by Bradley, Paul A.; Carroll, Robert J.; Lecouturier, Yann C.; Moore, Robert; Noeureuil, Pierre; Patel, Bhairavi; Snow, Jonathan; Wheeler, Simon

Book ID
120318287
Publisher
American Chemical Society
Year
2010
Tongue
English
Weight
245 KB
Volume
14
Category
Article
ISSN
1083-6160

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The synthesis of b 3 -adrenergic receptor agonists A and B with radiolabeled amide fragment, required for drug disposition studies, was accomplished based on initial formation of 2-(4-(2-amino-2-methylpropyl)phenoxy)-5-[ 14 C]-cyanopyridine by the reaction of 2-bromo-5-iodopyridine with para-substit