𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Alternate Synthesis of a β-3 Adrenergic Receptor Agonist

✍ Scribed by Scott, Robert W.; Fox, Darrell E.; Wong, John W.; Burns, Michael P.


Book ID
120503085
Publisher
American Chemical Society
Year
2004
Tongue
English
Weight
150 KB
Volume
8
Category
Article
ISSN
1083-6160

No coin nor oath required. For personal study only.


📜 SIMILAR VOLUMES


Practical chemoenzymatic synthesis of a
✍ John Y.L Chung; Guo-Jie Ho; Michel Chartrain; Chris Roberge; Dalian Zhao; John L 📂 Article 📅 1999 🏛 Elsevier Science 🌐 French ⚖ 293 KB

A chemoenzymatic synthesis of 133 agonist 1 suitable for large scale preparation is described. The key chiral 3pyridylethanolamine intermediate (R)-7 was prepared via an improved Neber rearrangement and a yeast-mediated asymmetric reduction. The tetrazolone fragment of the molecule was constructed v

Convergent synthesis of two 14C-labeled
✍ Boris A. Czeskis; William J. Wheeler; Dean K. Clodfelter 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 French ⚖ 148 KB

The synthesis of b 3 -adrenergic receptor agonists A and B with radiolabeled amide fragment, required for drug disposition studies, was accomplished based on initial formation of 2-(4-(2-amino-2-methylpropyl)phenoxy)-5-[ 14 C]-cyanopyridine by the reaction of 2-bromo-5-iodopyridine with para-substit