A chemoenzymatic synthesis of 133 agonist 1 suitable for large scale preparation is described. The key chiral 3pyridylethanolamine intermediate (R)-7 was prepared via an improved Neber rearrangement and a yeast-mediated asymmetric reduction. The tetrazolone fragment of the molecule was constructed v
✦ LIBER ✦
Alternate Synthesis of a β-3 Adrenergic Receptor Agonist
✍ Scribed by Scott, Robert W.; Fox, Darrell E.; Wong, John W.; Burns, Michael P.
- Book ID
- 120503085
- Publisher
- American Chemical Society
- Year
- 2004
- Tongue
- English
- Weight
- 150 KB
- Volume
- 8
- Category
- Article
- ISSN
- 1083-6160
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