Diastereoselective hydrogenation of N-protected y-amino fi-keto esters catalyzed by BINAP-Ru(II) complexes provides an efficient entry to the statine series with high enantiomeric purities.
β¦ LIBER β¦
The Synthesis of Tenofovir and Its Analogues via Asymmetric Transfer Hydrogenation
β Scribed by Zhang, Qian; Ma, Bai-Wei; Wang, Qian-Qian; Wang, Xing-Xing; Hu, Xia; Xie, Ming-Sheng; Qu, Gui-Rong; Guo, Hai-Ming
- Book ID
- 121878058
- Publisher
- American Chemical Society
- Year
- 2014
- Tongue
- English
- Weight
- 518 KB
- Volume
- 16
- Category
- Article
- ISSN
- 1523-7060
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## Abstract Full details of the asymmetric total synthesis of erythro-8-O-4β²-neolignan, machilin C, and its analogue perseal A are reported. The synthesis was involved in the Sharpless dihydroxylation reaction that occurred with excellent asymmetric induction, and the Mitsunobu reaction which occur