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The synthesis of substituted (4S)-4-(hydroxymethyl)imidazolidin-2-ones as novel protein kinase C modulators

✍ Scribed by Lianyun Zhao; Lixin Qiao; Suo-Bao Rong; Alan P Kozikowski

Publisher: Elsevier Science
Year: 2000
Tongue: French
Weight: 133 KB
Volume: 41
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(00)01561-6

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✦ Synopsis

The total synthesis of substituted (4S)-4-(hydroxymethyl)imidazolidin-2-ones from D-serine methyl ester is described. The key step in the synthesis is a reductive amination reaction which is brought about using titanium(IV) isopropoxide and sodium cyanoborohydride, followed by the cyclization to urea using triphosgene after deprotection.

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