New Potent Sialyltransferase Inhibitors—
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Franz Amann; Christoph Schaub; Bernd Müller; Richard R. Schmidt
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Article
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1998
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John Wiley and Sons
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English
⚖ 286 KB
👁 2 views
Enzymatic sialyl transfer with CMP-Neu5Ac as donor can be inhibited by CDP. Therefore phosphonates 1 a,b, 2 and 3 were synthesized as substrate analogues. With a(2 ± 6)-sialyltransferase from rat liver (EC 2.4.99.1) only moderate inhibition was found for these compounds. In order to obtain transitio