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The synthesis of phosphorylated 3?-amino-3?-deoxythymidine and 5?-amino-5?-deoxythymidine

โœ Scribed by Glinski, Ronald P.; Khan, M. Sami; Kalamas, Richard L.; Stevens, Calvin L.; Sporn, Michael B.


Book ID
121183179
Publisher
Royal Society of Chemistry
Year
1970
Weight
220 KB
Volume
0
Category
Article
ISSN
0577-6171

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๐Ÿ“œ SIMILAR VOLUMES


Conformationally locked nucleosides. Syn
โœ Guangyi Wang ๐Ÿ“‚ Article ๐Ÿ“… 1999 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 226 KB

3'-Amino-3'-deoxythymidine was converted, in multi-steps, to its 5'-O-(4,4'-dimethoxytrityl)-5'-C-tosyloxyethyl-3'-N-carbobenzoxy derivative 7 and 5'-C-mesyloxyethyl-3'-N-(9-fluorenyl)methoxycarbonyl derivatives 6 and 11. Subsequent hydrogenolysis or treatment with DMAP afforded 3'-N,5'-C-bridged bi