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Inhibition of mammalian dna polymerase-associated 3′ to 5′ exonuclease activity by 5′-monophosphates of 3′-azido-3′-deoxythymidine and 3′-amino-3′-deoxythymidine

✍ Scribed by Edward G. Bridges; Abdesslem Faraj; Jean-Pierre Sommadossi


Book ID
115783342
Publisher
Elsevier Science
Year
1993
Tongue
English
Weight
520 KB
Volume
45
Category
Article
ISSN
0006-2952

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Inhibition of hepatitis B virus DNA poly
✍ E. Nordenfelt; Bengt Löfgren; Jyoti Chattopadhyaya; Bo Öberg 📂 Article 📅 1987 🏛 John Wiley and Sons 🌐 English ⚖ 301 KB 👁 2 views

An inhibitory effect of 3'-azido-3'-deoxythymidine triphosphate on hepatitis B virus DNA polymerase was found. No effect was seen by its threo analog. The effect was detected at and above a concentration of 0.05 microM. The inhibition of DNA polymerase activity was the same in ten different strains