Synthesis of novel β-substituted α,β-deh
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Paula M.T Ferreira; Hernâni L.S Maia; Luı́s S Monteiro; Joana Sacramento
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Article
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2000
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Elsevier Science
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French
⚖ 88 KB
b-Substituted a,b-dehydroamino acids are synthesised in high yields by a Michael addition of heterocyclic nucleophiles to the methyl esters of N-tert-butyloxycarbonyl,N-(4-toluenesulfonyl)dehydroamino acids, followed by a base-induced elimination of the 4-toluenesulfonyl group with regeneration of t