The synthesis of methoxy and keto mycolic acids containing methyl-trans-cyclopropanes
β Scribed by Koza, Gani; Muzael, Maged; Schubert-Rowles, Richard R.; Theunissen, Cornelia; Al Dulayymi, Juma'a R.; Baird, Mark S.
- Book ID
- 120437154
- Publisher
- Elsevier Science
- Year
- 2013
- Tongue
- French
- Weight
- 967 KB
- Volume
- 69
- Category
- Article
- ISSN
- 0040-4020
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Z)-Tetracos-5-enoic acid is a key intermediate in the biosynthesis of mycobacterial mycolic acids. Recently the methyl ester of its cyclopropene analogue, methyl 4-(2-octadecylcyclopropcn-l-yl)butanoate, was shown to act as an inhibitor of mycolic acid biosynthesis. The related analogues methyl 5-(2
Trans mycolic acid content is directly related to cell wall fluidity and permeability in mycobacteria. Carbon-13 NMR spectroscopy of mycolic acids isolated from Mycobacterium tuberculosis (MTB) and Mycobacterium smegmatis (MSM) fed 13 C-labeled precursor molecules was used to probe the biosynthetic