The synthesis of lysergic acid derivatives from elymoclavine
β Scribed by Tung-Chung Choong; H.Richard Shough
- Publisher
- Elsevier Science
- Year
- 1977
- Tongue
- French
- Weight
- 97 KB
- Volume
- 18
- Category
- Article
- ISSN
- 0040-4039
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π SIMILAR VOLUMES
## Abstract The conformations of dihydrolysergamides and 10βmethoxydihydrolysergamides have been inferred from the study of the chemical shifts of the amide hydrogens and their temperature dependence. The ^13^C chemical shifts have been shown to be sensitive to conformational changes of the piperid
## Abstract Isomers of lysergic acid derivatives (**3**, **22**, **23** and **24**). analogous to aporphine, have been synthesized from the key intermediate ketone **12**.
The preparation of lysergic acid -die.thylmnide i s described. 14C -Diethylamine was synthesised i n three steps; ## sodium / 4 C l # ~c e t a t e was treated with thionyl chloride giving [14CI)-acetyZ chZoride which WIS reacted with ethylmnine t o give -N-ethyl-(14Cl]-acetwiide. Reduction of t h i