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The Synthesis of l-Ascorbic Acid Uniformly Labeled with C14

✍ Scribed by Bothner-By, A. A.; Gibbs, M.; Anderson, R. C.


Book ID
121143545
Publisher
American Association for the Advancement of Science
Year
1950
Tongue
English
Weight
80 KB
Volume
112
Category
Article
ISSN
0036-8075

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## Abstract L‐ascorbic‐6‐^14^C acid with a specific activity of 3.25 ΞΌCi/mg was prepared from D‐glucose‐1‐^14^C in an overall yield of 10 %. Synthetic steps were : glucose to sorbitol, sorbose, diisopropylidene sorbose, potassium diisopropylidene 2‐ketogulonate, 2‐ketogulonic acid and ascorbic acid

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14C-labeled chlorogenic acid (specijic activity 30.6 nCilmg) was synthesized by reaction of diphenylmethyl-I-0-ethoxy-carbonyl- 4,5-0-isopropylidenequinate ( V ) with 0,O-dimethylcarbonyl caffeoyl chloride-u-14C (VIII) followed by selective hydrolysis of the protecting groups.