The Synthesis of l-Ascorbic Acid Uniformly Labeled with C14
β Scribed by Bothner-By, A. A.; Gibbs, M.; Anderson, R. C.
- Book ID
- 121143545
- Publisher
- American Association for the Advancement of Science
- Year
- 1950
- Tongue
- English
- Weight
- 80 KB
- Volume
- 112
- Category
- Article
- ISSN
- 0036-8075
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π SIMILAR VOLUMES
## Abstract Lβascorbicβ6β^14^C acid with a specific activity of 3.25 ΞΌCi/mg was prepared from Dβglucoseβ1β^14^C in an overall yield of 10 %. Synthetic steps were : glucose to sorbitol, sorbose, diisopropylidene sorbose, potassium diisopropylidene 2βketogulonate, 2βketogulonic acid and ascorbic acid
14C-labeled chlorogenic acid (specijic activity 30.6 nCilmg) was synthesized by reaction of diphenylmethyl-I-0-ethoxy-carbonyl- 4,5-0-isopropylidenequinate ( V ) with 0,O-dimethylcarbonyl caffeoyl chloride-u-14C (VIII) followed by selective hydrolysis of the protecting groups.