The synthesis of key intermediates in cembranolides
β Scribed by Zhi-Cai Wang; Qi-Huang Zheng; Bi Gao; Shi-Yan Fan
- Book ID
- 112060256
- Publisher
- John Wiley and Sons
- Year
- 2010
- Tongue
- English
- Weight
- 352 KB
- Volume
- 12
- Category
- Article
- ISSN
- 0256-7660
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Enantiomerically pure 4-chlorothieno [3.4-d]imidazol-2-one (+)-2 and thieno[3,4-aimidazol-2,ddione (+)-5, key intermediates in independent routes to (+)-biotin ( ), have been prepared by resolution via the corresponding diastereomeric ethers (3d-g and 3'd-g). Efficient procedures to recycle the unde
## Abstract An enantioselective synthesis of key intermediates for the synthesis of the antiβmicrobially active pseudomonic acids **A** (**1**), **B** (**2**) and **C** (**3**) is described. DβRibose (**4**) was used as starting material.