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Synthesis of (+)-biotin: efficient resolution of key intermediates

✍ Scribed by Ron Bihovsky; Veeraiah Bodepudi

Book ID
104205116
Publisher
Elsevier Science
Year
1990
Tongue
French
Weight
661 KB
Volume
46
Category
Article
ISSN
0040-4020

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✦ Synopsis

Enantiomerically pure 4-chlorothieno [3.4-d]imidazol-2-one (+)-2 and thieno[3,4-aimidazol-2,ddione (+)-5, key intermediates in independent routes to (+)-biotin ( ), have been prepared by resolution via the corresponding diastereomeric ethers (3d-g and 3'd-g). Efficient procedures to recycle the undesired diastereomers and recover the chiral auxiliary have been developed.

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