The synthesis of (+)-hedycaryol, starting from natural (−)-guaiol

✍ Scribed by Adriaan J. Minnaard; Joannes B.P.A. Wijnberg; Aede de Groot

• Book ID: 104203084
• Publisher: Elsevier Science
• Year: 1994
• Tongue: French
• Weight: 795 KB
• Volume: 50
• Category: Article
• ISSN: 0040-4020
• DOI: 10.1016/s0040-4020(01)85014-6

✦ Synopsis

Starting from the readily available (-)-guaiol the germacrane sesquiterpene I+)hedycayol

can be synthesized in a 7 steps reaction sequence in an overall yield of 16%.

Additionally, (+)-peudesmol has been synthesized, also starting from I-)-guaiol.