The synthesis of E-(2s, 3s)-3-trimethylsilylglycidol and its conversion to (−)-propranolol

✍ Scribed by Tsutomu Katsuki

• Book ID: 104233668
• Publisher: Elsevier Science
• Year: 1984
• Tongue: French
• Weight: 105 KB
• Volume: 25
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(01)81299-5

✦ Synopsis

Institute of Technology, highly enantio-and regioselective manner by using titanium mediated asymmetric epoxidation via the key intermediate, E-(2S,3S)-3-trimethylsilylglycidol.

Chiral glycidol and its derivatives are versatile intermediates in the synthesis of the natural products. 1) However, glycidol is so unstable that it