β Scribed by Crist N. Filer
No coin nor oath required. For personal study only.
The preparation of dopaminergic ligands radiolabelled with either tritium or iodineβ125 has been an extremely important undertaking to advance understanding of this critical receptor class and the topic is reviewed from 1976 through 2006. Although not an exhaustive compilation of references, the cited examples highlight the many methods employed to prepare these useful reagents. Copyright Β© 2007 John Wiley & Sons, Ltd.
π SIMILAR VOLUMES
## Abstract Iodineβ125 labelled vinyl and aryl iodides are formed via the reaction of sodium iodideβ125 with vinylβ and arylboronic acids. Good yields of isomerically pure products are obtained.
d e r i v a t i v e s of 2 and 2 were req u i r e d f o r b i o d i s t r i b u t i o n s t u d i e s . U t i l i z i n g a new exchange p r o c e d u r e t h e s e r a d i o i o d i n a t e d a n a l o g u e s were s y n t h e s i z e d w i t h r a d i o c h e m i c a l y i e l d s r a n g i n g fr
w-[ 1251]Iodoundecyl choleeteryl ether has been synthesized via a hydroboration-iodination sequence. The syntheses can be used to prepare high specific activity (no-carrier-added) reagents.
The synt esis of 3H-labelled azidothymidine (AZT) from accomplished by column chromatography. The purity of the labelled compound was determined by high performance 1 iquid chromatography connected with a radioactive flow detector. The labelled AZT was found to be stable at pH ranging from 2.3 to 7.
## Abstract Tritium labelled pentamidine has been prepared with a specific activity of 90 mCi mmol^β1^ using a oneβstep exchange reaction between the unlabelled drug and tritiated water. The labelling utilised a homogeneous rhodium trichloride catalyst and yielded pentamidine regiospecifically labe