The Synthesis of Dibenzyl trans-{7-oxo-3-phenyl-6-phenylacetamido-1-azabicyclo [3.2.0]heptane}-2,2-dicarboxylate (Carbapenam)
β Scribed by Gholam Hosein Hakimelahi; Antonio Ugolini; George Just
- Publisher
- John Wiley and Sons
- Year
- 1982
- Tongue
- German
- Weight
- 239 KB
- Volume
- 65
- Category
- Article
- ISSN
- 0018-019X
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β¦ Synopsis
Abstract
The synthesis of the title compound is described.
π SIMILAR VOLUMES
The title compound was prepared in good yield via intramolecular insertion of an a-alkoxycarbonyl, a-sulphonyl carbene into the N-H bond of an azetidinone. Esters of (k) 7-oxo-3-thia-l-azabicyclo[3.2.0lheptane-2-carboxylate-3,3-dioxide, 1, are potentially useful intermediates in the synthesis of no
The synthesis of a d'carbapenem and two ,?-lactams possessing a Br-atom at the N-substituting center not involved in the lactam ring and bearing the carboxyl group is described. The ,?-lactams having this kind of Br-substitution are more susceptible to nucleophilic attack than those having a conjuga
3R)-4-Acetoxy-3-trimethylsilyl-2-azetidinone, was converted into optically pure benzyl penicillanate in seven steps (22%) using (benzyloxy)nitromethane as a reagent for ring annulation.