𝔖 Bobbio Scriptorium
✦   LIBER   ✦

The synthesis of conformationally constrained analogues of the ACE inhibitor Idrapril

✍ Scribed by Iwan G Jones; Wyn Jones; Michael North

Publisher
Elsevier Science
Year
1999
Tongue
French
Weight
671 KB
Volume
55
Category
Article
ISSN
0040-4020

No coin nor oath required. For personal study only.

✦ Synopsis

A conformationally constrained analogue 3 of the ACE inhibitor Idrapril has been prepared by a five-step synthesis. The key step in the synthesis is the desymmetrization of endo-norbom-5-ene-2,3-dicarboxylic anhydride 4 by reaction with t-butyl (S)-prolinate.

πŸ“œ SIMILAR VOLUMES

Synthesis of conformationally constraine
Synthesis of conformationally constrained spirodihydrofuropyridine analogues of epibatidine
✍ Hideki Abe; Yumiko Arai; Sakae Aoyagi; Chihiro Kibayashi πŸ“‚ Article πŸ“… 2003 πŸ› Elsevier Science 🌐 French βš– 99 KB

Conformationally constrained spirofuropyridine analogues of epibatidine, syn-2 and anti-2, in which the 7-azabicyclo[2.2.1]heptane system and the 2-chloropyridine ring are held rigidly with the shorter and longer N-N distances, respectively, were synthesized from N-Boc-7-azabicyclo[2.2.1]heptan-2-on

Azabicycloalkenes as Synthetic Intermedi
Azabicycloalkenes as Synthetic Intermediates – Synthesis of Conformationally Constrained Glutamate Analogues
✍ Wolfgang Maison πŸ“‚ Article πŸ“… 2007 πŸ› John Wiley and Sons 🌐 English βš– 177 KB

## Abstract As a part of our study of the cancer‐specific protease PSMA (prostate‐specific membrane antigen) we present a stereoselective synthesis of conformationally constrained glutamate mimetics. Key intermediates are azabicycloalkenes which are synthesized via diastereoselective or enantiosele