The Synthesis of cis and trans Olefins via β-Keto and β-Hydroxy Phosphonamides
✍ Scribed by Corey, E. J.; Kwiatkowski, George T.
- Book ID
- 121015785
- Publisher
- American Chemical Society
- Year
- 1966
- Tongue
- English
- Weight
- 296 KB
- Volume
- 88
- Category
- Article
- ISSN
- 0002-7863
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📜 SIMILAR VOLUMES
Lipases A and B from Candida antarctica are shown to be highly efficient and complementary biocatalysts for the resolution of five-to seven-membered cyclic b-hydroxy esters by O-acylation. Using this procedure, all four stereoisomers of each one are obtained in enantiopure form and very high yields.
Enantiomerically pure acylketene acetals were employed to generate a homochiral p-keto ketal through a highly diastereoselective lithium enolate quench. The fi-keto ketal, which was also prepared through a desymmetrization ketulizution reaction on a meso dione, was employed in the synthesis of the i