The synthesis of both enantiomers of lactobacillic acid and mycolic acid analogues

✍ Scribed by Geoffrey D. Coxon; Stefan Knobl; Evan Roberts; Mark S. Baird; Juma R. Al Dulayymi; Gurdyal S. Besra; Patrick J. Brennan; David E. Minnikin

• Publisher: Elsevier Science
• Year: 1999
• Tongue: French
• Weight: 219 KB
• Volume: 40
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(99)01378-7

✦ Synopsis

I1R, 12S)-Lactobacillic acid (1) has been prepared either from D-mannitol by asymmetric cyclopropanation or from cis-cy¢lopropane-l, 2-dimethanol by enzymatic dssymmetfisation. The syntheses of (IIS 12R)-lactobacillic acid ( 2) and (1R, 2S) l-(3'-methoxycmbonyipropyl)-2-octadecylcyciopropane (26) and related analogues (27 and 28) have also been achieved.