The Synthesis of Azapeptidomimetic β-Lactam Molecules as Potential Protease Inhibitors.
✍ Scribed by William P. Malachowski; Chenyang Tie; Katherine Wang; Robert L. Broadrup
- Publisher
- John Wiley and Sons
- Year
- 2003
- Weight
- 291 KB
- Volume
- 34
- Category
- Article
- ISSN
- 0931-7597
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## Abstract The synthesis of __gem__‐difluorinated β‐lactams and __gem__‐difluorinated β‐amino acids, each possessing a potential basic functional group, from ethyl bromodifluoroacetate and either imines (for β‐lactams) or __N__‐(α‐aminoalkyl)benzotriazoles (for β‐amino esters) was investigated. A