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The synthesis of anomeric 3-O-acetyl-5-O-benzoyl-2-azido-2-deoxy-D-arabinofuranosyl chlorides. Versatile sugar intermediates for the synthesis of 2′-azido-2′-deoxy- and 2′-amino-2′-deoxy-β-D-arabinofuranosyl nucleosides.

✍ Scribed by Miroslav Bobek; Vicki Martin

Publisher
Elsevier Science
Year
1978
Tongue
French
Weight
226 KB
Volume
19
Category
Article
ISSN
0040-4039

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✦ Synopsis

Considerable effort has been devoted over the years to the synthesis of amino nucleosides spurred on largely by the antibiotic properties exhibited by many of them. l-4 However, the synthesis of 2'-amino-2'-deoxy nucleosides which have the amino group in the "up" (arabino) configuration has proved rather elusive.

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