Ξ±-methyl amino acids by catalytic phase-
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Martin J. O'Donnell; Brigitte LeClef; David B. Rusterholz; LΓ©on Ghosez; Jean-Pie
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Article
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1982
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Elsevier Science
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French
β 195 KB
The a-methyl amino acids, a-methyl p-chlorophenylalanine, a-methyl p-tyrosine, amethyl m-tyrosine and a-methyl DOPA have been prepared in good yields from amino ester hydrochlorides. The key step in the method is the catalytic phase-transfer alkylation of Schiff base derivatives of monoalkyl amino