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The synthesis of allyl- and allyloxycarbonyl-protected RNA phosphoramidites. Useful reagents for solid-phase synthesis of RNAs with base-labile modifications

✍ Scribed by Felicia M. Bogdan; Christine S. Chow

Publisher: Elsevier Science
Year: 1998
Tongue: French
Weight: 249 KB
Volume: 39
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(98)00157-9

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✦ Synopsis

The synthesis of atlyl-and allyloxycarbonyl (AOC)-protected RNA phosphoramidites is reporlexl. The use of allyl and AOC groups allows the chemistry of solid-phase RNA synthesis to be expanded to include base-labile modified nucleosides, such as acetylcytidine. The allyl-and AOCprotective chemistry can be further expanded for the construction of RNAs on solid supports and affinity columns.

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