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The synthesis of a key intermediate en route to gelsemine: a program based on intramolecular displacement of the carbonoxygen bond of a strategic oxetane

✍ Scribed by Fay W Ng; Hong Lin; Qiang Tan; Samuel J Danishefsky

Book ID: 104232253
Publisher: Elsevier Science
Year: 2002
Tongue: French
Weight: 126 KB
Volume: 43
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(01)02212-2

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✦ Synopsis

The synthesis of key intermediate 30 en route to gelsemine has been accomplished from known aldehyde 10 via oxetane 19 featuring stereospecific Claisen rearrangement and Lewis acid-catalyzed oxetane ring opening.

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