The synthesis of 8-substituted tetracycline derivatives, the first 8-position carbon–carbon bond
✍ Scribed by Darrell J Koza
- Book ID
- 108379826
- Publisher
- Elsevier Science
- Year
- 2000
- Tongue
- French
- Weight
- 127 KB
- Volume
- 41
- Category
- Article
- ISSN
- 0040-4039
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📜 SIMILAR VOLUMES
I-Substituted te.mcycm. otiho&bmam' meS, ticatalyzed azide rearrangements. 7(or 9)-azimyclines Abstract llwC-8 funcdooalizatiooof te~clinederivatives via acid-catalyzed reatIangemf%It Of 7(or 9)azieyclines is c%zscribed. These ccmpomaaretbefifsttobepreparedfmulanin~ttehacyclincnucleus.
## Abstract The asymmetric synthesis of α‐substituted α‐amino acids and propargylamines is described. As chiral auxiliary we used (__S__)‐(–)‐1‐dimethoxymethyl‐2‐methoxymethylpyrrolidine (SDMP, **1**). Treatment of the amino acids or amines with SDMP **1** afforded the corresponding amidines **C**,