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The synthesis of 6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidines. II. 4-Hydroxy, 4-mercapto, 2-amino-4-hydroxy and 2,4-dihydroxy derivatives

✍ Scribed by Tuvia Sheradsky; Philip L. Southwick


Book ID
112121537
Publisher
Journal of Heterocyclic Chemistry
Year
1967
Tongue
English
Weight
560 KB
Volume
4
Category
Article
ISSN
0022-152X

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Synthesis of 2-amino-3,5-dihydro-7-(3-th
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## Abstract 2‐Amino‐3,5‐dihydro‐7‐(3‐thienylmethyl)‐[6‐^14^C]‐4H‐pyrrolo [3,2‐d]pyrimidin‐4‐one monohydrochloride ([^14^C]Cl‐1000), a potent purine nucleoside phosphorylase inhibitor, was made in six steps from potassium [^14^C]cyanide. A key step was the reduction of a nitro and a nitrile group wi