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A short, facile synthesis of 2-amino-1,5-dihydro-4H-pyrrolo[3,2-d]-pyrimidin-4-one (9-Deazaguanine)

✍ Scribed by Arthur J. Elliott; John A. Montgomery; David A. Walsh


Book ID
103407070
Publisher
Elsevier Science
Year
1996
Tongue
French
Weight
102 KB
Volume
37
Category
Article
ISSN
0040-4039

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Synthesis of 2-amino-3,5-dihydro-7-(3-th
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## Abstract 2‐Amino‐3,5‐dihydro‐7‐(3‐thienylmethyl)‐[6‐^14^C]‐4H‐pyrrolo [3,2‐d]pyrimidin‐4‐one monohydrochloride ([^14^C]Cl‐1000), a potent purine nucleoside phosphorylase inhibitor, was made in six steps from potassium [^14^C]cyanide. A key step was the reduction of a nitro and a nitrile group wi