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The synthesis of 2,3,5,6-tetrahydroimidazo [2, 1-b] thiazoles utilising α-bromo-Michael acceptors

✍ Scribed by R. Bayles; P.W.R. Caulkett; T.P. Seden; R.W. Turner


Publisher
Elsevier Science
Year
1975
Tongue
French
Weight
166 KB
Volume
16
Category
Article
ISSN
0040-4039

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A facile approach to the synthesis of 2,3,6-trisubstituted-5,6-dihydroimidazo[2,1-b]thiazole was reported. A resin bound cyclic thiourea was formed by the treatment of a resin bound diamine with 1,1'-thiocarbonyldiimidazole, and then reacted with a α-haloketone to generate a resin bound isothiourea.