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The synthesis of 2,2-d2-cyclohexanone and 2,2-d2-cyclopentanone

✍ Scribed by Joseph Deutsch; Asher Mandelbaum


Book ID
104239210
Publisher
Elsevier Science
Year
1969
Tongue
French
Weight
97 KB
Volume
10
Category
Article
ISSN
0040-4039

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✦ Synopsis


The synthesis of deuterium labelled organic compounds has been of great importance in the investigation of the mechanisms of organic reactions, in n.m.r. studies and in the determination of fragmentation patterns under electron impact. Rather few examplesof partial


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## Abstract A convenient method for the synthesis of cyclopropyl cyanide‐2,2‐d~2~ has been elaborated. Reduction of methyl 3‐cyanopropionate with lithium borodeuteride followed by reaction of the resulting alcohol with triphenylphosphine and carbon tetrachloride gave 4‐chlorobutyronitrile‐4,4‐d~2~.