The synthesis of 2-O-alkyl-myo-inositol 1-phosphates as competitive inhibitors of inositol monophosphatase
โ Scribed by Michael G.N. Russell; Raymond Baker; David C. Billington
- Publisher
- Elsevier Science
- Year
- 1992
- Tongue
- English
- Weight
- 423 KB
- Volume
- 234
- Category
- Article
- ISSN
- 0008-6215
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## Abstract A mixture of DLโ[^2^H~6~]myoโinositolโ1โ and โ4โphosphate and (meso) myoโinositolโ2โ and โ5โphosphate is readily prepared on a 100 milligram scale from the mixed isomers of diโOโcyclohexylideneโ[^2^H~6~]myoโinositol by phosphorylation with tetrabenzylpyrophosphate. The deblocked [^2^H~6
Inositol monophosphatase plays a pivotal role in the biosynthesis of secondary messengers and is believed to be a target for lithium therapy. It is established how a lithium ion works in inhibiting the enzyme but details of the mechanism for the direct magnesium ion activated hydrolysis of the subst