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The synthesis of 2-morpholine carboxylic acid derivatives and their elaboration to 1-aza-4-oxabicyclo[3.3.1]nonan-6-one.

✍ Scribed by Frank D. King; Roger T. Martin


Book ID
108381492
Publisher
Elsevier Science
Year
1991
Tongue
French
Weight
212 KB
Volume
32
Category
Article
ISSN
0040-4039

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Synthesis of (Β±)-3-amino-2,4-dihydroxy-6
✍ Seiichiro Ogawa; Masaru Orihara πŸ“‚ Article πŸ“… 1989 πŸ› Elsevier Science 🌐 English βš– 605 KB

Nitromethane-mediated cyclization of the dialdehyde generated by periodate oxidation of (+)-2exo,3exo-dihydroxy-5endo-hydroxymethyl-7-oxabicyclo[2.2.1]heptane (2) in methanolic sodium methoxide afforded, after neutralisation, three diastereoisomers (4.a-6a) of (f )-2,4-dihydroxy-&hydroxymethyl-3-nit